*ABBO2814 M04-697 (2006)
A Phase 3, Randomized, Multicenter, Double-Blind Study Comparing the Analgesic Efficacy of (the study drug) to Placebo in Subjects With Osteoarthritis.

*Hisamitsu HKT-500-US05 (2006)
A Randomized, Multicenter, Double-Blind, Placebo-Controlled, Two-Week Study to Assess the Safety and Efficacy of (the study drug) in Subjects with Pain from Moderate Lateral Epicondylitis.

GlaxoSmithKline SB-767905/014 (2005-2006)
A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Phase 3 Study to Evaluate the Long-Term Safety of (the study drug) for 12 Months in the Treatment of Opioid-Induced Bowel Dysfunction in Adults taking Opioid Therapy for Persistent Non-Cancer Pain.

*Hisamitsu HKT-500-US06 (2005)
An Open Label Safety Study with Intermittent Use of (the study drug) in Subjects with Lower Back Pain, Pain from Osteoarthritis of the Knee, Shoulder Pain or Lateral Epicondylitis Pain.

*ABBO2814 M03-666 (2005)
An Open Label Study Evaluating the Safety and Tolerability of Long Term Administration of (the study drug) in Subjects with Moderate to Severe Chronic Non-Malignant Pain.

Guilford Pharmaceuticals 3000-0412 (2004-2005)
A Phase III, Randomized, Open-Label Study to Assess the Safety and Efficacy of (the study drug) versus Midazolam HCl for Sedation in Patients Undergoing Minor Surgical Procedures.

*ABBO2814 M03-643 (2004-2005)
A Randomized, Multi-Center Double-Blind Study Comparing the Analgesic Efficacy of (the study drug) and Placebo in Subjects with Osteoarthritis.

AlgoRx Pharmaceuticals, Inc. 4975-2-003-1 (2004-2005)
Randomized, Double-Blind, Placebo-Controlled Dose Ranging Trial of (the study drug) in Subjects Undergoing Bunionectomy with First Metatarsal Osteotomy Surgery.

* Principle Investigator